1Wyszukiwanie od początku wyrazu:Wyraz preane znajdzie "preanestetyczny", ale anestetyczny nie znajdzie tego słowa (wyszukiwanie patrzy tylko na początek wyrazów)
-Wykluczanie słów (znak minus):Poprzedzenie wyrazu znakiem - znajdzie wszystkie tytuły NIE zawierające danego słowa, np. -onkologia znajdzie prace bez słowa "onkologia"
"Wyszukiwanie całych fraz (cudzysłów):Cudzysłów powoduje szukanie całych ciągów znaków w tej samej kolejności. Np. "Uniwersytet Medyczny" wyszuka tylko prace z dokładnie tą nazwą, podczas gdy wpisanie bez cudzysłowu może znaleźć "Medyczny Uniwersytet"
↕Nawigacja klawiaturą:Użyj / aby otworzyć wyszukiwanie, strzałek ↑↓ do nawigacji po wynikach, ENTER aby przejść do wybranej pozycji, lub ESC aby zamknąć okno
Porady BPP:Ładowanie porad...
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Biblioteka informuje, że dla artykułów z lat 2024-2025 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2025
Biblioteka informuje, że dla artykułów z lat 2023-2024 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2024
Biblioteka informuje, że dla artykułów z lat 2022-2023 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2023
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. Xanthohumol (XN) exhibits anti-inflammatory, anti-oxidant, anti-fibrotic, anti-microbial, anti-proliferative, and immunomodulatory effects that all are associated with the IgAN pathogenesis. Our study aims to evaluate the potential impact of XN on the clinical course of IgAN refractory to conventional treatment. Included were five rigorously selected IgAN patients with poor prognosis assessed on the basis of clinical findings and renal biopsy. Patients received XN orally at a daily dose of 2 mg/kg body weight. Biochemical tests were performed the day before the start of XN administration, and then after 2, 4, 12, 24, and 52 weeks of XN administration. XN induced a decrease in daily proteinuria in all patients. Compared to baseline values, at T52 the mean reduction in proteinuria and albumin-creatinine-ratio …
AbstractHot-melt extrusion is an effective method for enhancing the solubility of weakly water-soluble compounds through amorphization, but the obtained powder form does not provide sufficient skin adherence or residence time, thus requiring incorporation into a suitable carrier for topical delivery. Hydrogels can serve as an appropriate carriers for such systems, offering additional characteristics such as self-healing and pH-responsiveness. Therefore, our research aimed to develop a hydrogel carrier with distinct features for a hot-melt extruded system containing curcumin and hesperetin, both having anti-cancer activity against skin cancer. We used a double cross-linking method with tannic acid and aluminum ions to prepare three hydrogels with different ratio of these agents, characterized by ATR-FTIR and rheological tests. Swelling studies in buffers of varying pH andin vitrorelease tests in pH …
Abstract Oxaliplatin (OXA), a third-generation platinum chemotherapeutic, is widely used against various malignancies but increasingly associated with male reproductive toxicity. The molecular mechanisms underlying germ cell dysfunction, however, remain unclear. In this study, we provide novel insights into the differential cellular responses of murine spermatogenic cell lines GC-1 (spg) and GC-2 (spd) to OXA exposure, focusing on key hallmarks of cytotoxicity, including metabolic disruption, oxidative stress, cell cycle perturbation, and apoptosis. Our findings reveal markedly higher susceptibility of GC-1 (spg) cells to OXA, characterized by significant reductions in viability and proliferation accompanied by G1 phase arrest and enhanced nuclear accumulation of phosphorylated p53, indicating activation of a DNA damage response. Both cell types exhibited elevated levels of intracellular ROS and distinct nuclear abnormalities, suggesting oxidative stress as a central mediator …
Abstract Beetroot (Beta Vulgaris) has garnered significant attention as a natural dietary supplement for enhancing athletic performance and endurance. Rich in nitrates, beetroot is converted into nitric oxide upon ingestion, improving blood flow, lung function, and muscle contraction. Recent studies highlighted beetroot's role in boosting endurance, athletic performance, and overall physical fitness. In addition to nitrates, beetroot contains an array of phytochemicals such as carotenoids, ascorbic acid, flavonoids, phenolic acids, and betalains. These bioactive compounds possess antioxidant, anti-inflammatory, and blood-enhancing properties, offering benefits like improved oxygen delivery and muscle recovery. Betalains, in particular, have shown promise in preventing muscle injury and mitigating oxidative stress. Available studies suggest that consuming approximately 500 mL of beetroot juice 2 to 3 h before exercise may enhance endurance and oxygen efficiency. However, there is …
Abstract Usnic acid (UA) is one of the most extensively studied specialized metabolites of lichens, attracting considerable interest due to its antimicrobial, anti-inflammatory, and cytotoxic properties. The efficiency of UA extraction from lichens depends on multiple interrelated biological and technological factors. This systematic review aims to synthesize and critically evaluate reported strategies for UA extraction from wild-grown lichen biomass, with particular emphasis on extraction efficiency, practicality, and application potential. This systematic literature review, based on the Scopus database was conducted by including original research articles reporting UA extraction from wild-growing lichens. The analysis covered species selection, sample pre-treatment, solvent type, and extraction methodology. A total of 117 studies were included. Due to the predominantly non-polar nature of UA, higher extraction efficiencies were generally achieved using solvents, including acetone, supercritical CO2, …
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