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• Nailfold capillaroscopy in rheumatic connective tissue diseases. [AUT. KORESP.] EWA WIELOSZ, [AUT.] NATALIA SIEDLECKA. Reumatologia [online] 2025 vol. 63 s. 1-6, bibliogr. poz. 37, [przeglądany 5 grudnia 2025]. Dostępny w: https://reu.termedia.pl/Nailfold-capillaroscopy-in-rheumatic-connective-tissue-diseases,211212,0,2.html. DOI: 10.5114/reum/211212
  05.12.2025 13:10 • 2025
• Zespół antyfosfolipidowy, toczeń układowy, choroby autoimmunologiczne a ciąża. W: Położnictwo. T. 1. Red. nauk. Piotr Sieroszewski, Sebastian Kwiatkowski Warszawa 2025, PZWL Wydawnictwo Lekarskie, s. 455-468, bibliogr. poz. 37, 978-83-01-24599-3. DOI: 10.53271/2025.185
  05.12.2025 12:13 • 2025
• Położnictwo. T. 1. [RED. NAUK.] PIOTR SIEROSZEWSKI, SEBASTIAN KWIATKOWSKI. Warszawa 2025, PZWL Wydawnictwo Lekarskie, s. 779, bibliogr, 978-83-01-24599-3. DOI: 10.53271/2025.185
  05.12.2025 12:13 • 2025
• Endovaginal urethra and bladder imaging. [AUT.] ANDRZEJ P. WIECZOREK, MAGDALENA M. WOŹNIAK. W: Practical pelvic floor ultrasonography : a multicompartmental approach to 2D/3D/4D ultrasonography of the pelvic floor. Third Edition. Ed. S. Abbas Shobeiri Cham 2025, Springer, s. 179-210, bibliogr. poz. 88, [przeglądany 2 grudnia 2025]. Dostępny w: https://link.springer.com/chapter/10.1007/978-3-031-92486-6_7, 978-3-031-92485-9. DOI: 10.1007/978-3-031-92486-6_7
  05.12.2025 12:11 • 2025
• Practical pelvic floor ultrasonography : a multicompartmental approach to 2D/3D/4D ultrasonography of the pelvic floor. Third Edition. [RED.] S. ABBAS SHOBEIRI. Cham 2025, Springer, ss. 505, bibliogr, [przeglądany 2 grudnia 2025]. Dostępny w: https://link.springer.com/book/10.1007/978-3-031-92486-6, 978-3-031-92485-9. DOI: 10.1007/978-3-031-92486-6
  05.12.2025 12:04 • 2025
• 1-[4-(4-Chlorophenyl)piperazin-1-yl]-2-[(4-phenyl-4H-1,2,4-triazol-3-yl)sulfanyl]ethan-1-one. [AUT.] WIKTORIA DRZAŁ, JAROSŁAW SOBSTYL, [AUT. KORESP.] NAZAR TROTSKO. Molbank [online] 2025 vol. 2025 nr 4 [art. nr] M2097, s. 1-7, bibliogr, [przeglądany 5 grudnia 2025]. Dostępny w: https://www.mdpi.com/1422-8599/2025/4/M2097DOI: 10.3390/M2097.
  05.12.2025 12:03 • 2025
• Blood derivatives in the therapy of ocular surface diseases. [AUT.] PIOTR STĘPIEŃ, TOMASZ ŻARNOWSKI, [AUT. KORESP.] DOMINIKA WRÓBEL-DUDZIŃSKA. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 11097, s. 1-39, bibliogr. poz. 177, [przeglądany 5 grudnia 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/11097. DOI: 10.3390/ijms262211097
  05.12.2025 11:58 • 2025
• Infrared (IR) imaging in forensic medicine: review of applications and perspectives. (Obrazowanie w podczerwieni (IR) w medycynie sądowej: przegląd zastosowań i perspektyw.). [AUT.] PAWEŁ KĘDZIERAWSKI, [AUT. KORESP.] ADAM BRACHET, [AUT.] MIKOŁAJ MARGAS, MARCIN CZECZELEWSKI, JACEK BAJ, GRZEGORZ TERESIŃSKI. Arch. Med. Sąd. 2025 t. 75 nr 3 s. 239-250, bibliogr. poz. 66, streszcz. DOI: 10.4467/16891716AMSIK.25.016.22660
  05.12.2025 11:43 • 2025
• Novel 1,4-benzothiazepin-2-one modulators of NCX3 as a promising strategy for neuroprotection in cerebral ischemia. [AUT.] ANTONIA SCOGNAMIGLIO, ANGELA CORVINO, AGATA ZIĘBA, AGNIESZKA A. KACZOR, AGNESE SECONDO, ANNA PANNACCIONE, TUOMO LAITINEN, PAOLO LUCIANO, ROCCO VITALONE, [AUT. KORESP.] ORNELLA CUOMO, [AUT.] ESTER LICASTRO, VIVIANA VISCARDI, [AUT. KORESP.] LUCIO ANNUNZIATO, [AUT.] FERDINANDO FIORINO, FRANCESCO FRECENTESE, ELISA MAGLI, ELISA PERISSUTTI, VINCENZO SANTAGADA, [AUT. KORESP.] GIUSEPPE PIGNATARO, [AUT.] GIUSEPPE CALIENDO, [AUT. KORESP.] BEATRICE SEVERINO. Biomed. Pharmacother. [online] 2025 vol. 193 [art. nr] 118709, s. 1-21, bibliogr. poz. 63, [przeglądany 31 października 2025]. Dostępny w: https://www.sciencedirect.com/science/article/pii/S0753332225009035. DOI: 10.1016/j.biopha.2025.118709
  05.12.2025 11:40 • 2025
• Micro-needling: current state of knowledge and clinical applications: a review. [AUT. KORESP.] AGNIESZKA CIOZDA, [AUT.] EWELINA FIRLEJ, WIOLETA KOWALSKA, MAGDALENA KWIATKOWSKA, JOANNA BARTOSIŃSKA. Post. Dermatol. Alergol. 2025 vol. 42 nr 5 s. 439-443, bibliogr. poz. 21. DOI: 10.5114/ada.2025.155419
  05.12.2025 11:38 • 2025
• Mechanistic insights into the anti-inflammatory and anti-proliferative effects of selected medicinal plants in endometriosis. [AUT. KORESP.] OLIWIA BURDAN, [AUT.] NATALIA PICHETA, JULIA PIEKARZ, KAROLINA DANIŁOWSKA, FILIP GAJEWSKI, KRZYSZTOF KUŁAK, RAFAŁ TARKOWSKI. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 10947, s. 1-21, bibliogr. poz. 72, [przeglądany 18 listopada 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/10947. DOI: 10.3390/ijms262210947
  05.12.2025 11:33 • 2025
• Oxidative stress-mediated neuroinflammation in the pathophysiology of schizophrenia. [AUT.] MATEUSZ TRUBALSKI, AGNIESZKA MARKIEWICZ-GOSPODAREK, MARTA ŻEREBIEC, JULIA POLESZAK, MIŁOSZ SZCZOTKA, RENATA MARKIEWICZ, BARTOSZ ŁOZA, [AUT. KORESP.] SYLWIA SZYMAŃCZYK. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 11139, s. 1-29, bibliogr. poz. 165, [przeglądany 19 listopada 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/11139. DOI: 10.3390/ijms262211139
  05.12.2025 11:32 • 2025

Najnowsze rekordy ze streszczeniem

• Mechanistic insights into the anti-inflammatory and anti-proliferative effects of selected medicinal plants in endometriosis. [AUT. KORESP.] OLIWIA BURDAN, [AUT.] NATALIA PICHETA, JULIA PIEKARZ, KAROLINA DANIŁOWSKA, FILIP GAJEWSKI, KRZYSZTOF KUŁAK, RAFAŁ TARKOWSKI. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 10947, s. 1-21, bibliogr. poz. 72, [przeglądany 18 listopada 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/10947. DOI: 10.3390/ijms262210947
  Endometriosis involves oestrogen-dependent chronic inflammation and the abnormal proliferation of ectopic endometrial tissue. Conventional hormonal therapies suppress systemic oestrogen, but do not fully address local oxidative and inflammatory signalling. This review provides a mechanistic synthesis of recent molecular evidence. This evidence is on four FDA-recognized (Food and Drug Administration) medicinal plants. These are Curcuma longa, Zingiber officinale, Glycyrrhiza glabra, and Silybum marianum. The review highlights their capacity to modulate key intracellular pathways. These pathways are implicated in endometriosis. The review covers the integration of phytochemical-specific actions within NF-κB- (nuclear factor kappa-light-chain-enhancer of activated B cells), COX-2-(Cyclooxygenase-2), PI3K/Akt-(PI3K/Akt signaling pathway), Nrf2/ARE-(Nuclear factor erythroid 2–related factor 2) and ERβ-(Estrogen receptor beta) mediated networks, which jointly regulate cytokine secretion, apoptosis, angiogenesis and redox balance in endometrial lesions. Curcumin downregulates COX-2 and aromatase while …
• Oxidative stress-mediated neuroinflammation in the pathophysiology of schizophrenia. [AUT.] MATEUSZ TRUBALSKI, AGNIESZKA MARKIEWICZ-GOSPODAREK, MARTA ŻEREBIEC, JULIA POLESZAK, MIŁOSZ SZCZOTKA, RENATA MARKIEWICZ, BARTOSZ ŁOZA, [AUT. KORESP.] SYLWIA SZYMAŃCZYK. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 11139, s. 1-29, bibliogr. poz. 165, [przeglądany 19 listopada 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/11139. DOI: 10.3390/ijms262211139
  Schizophrenia is a complex neuropsychiatric disorder characterized by a diverse range of symptoms, including positive, negative symptoms such as alogia, anhedonia, avolition, and affective flattening, cognitive symptoms, and emotional symptoms as a separate domain. Emerging evidence suggests that oxidative stress and neuroinflammation play crucial roles in the etiopathogenesis of schizophrenia. The aim of this review is the interplay between oxidative stress—defined as an imbalance between reactive oxygen species (ROS) production and antioxidant defenses—and neuroinflammatory processes within the central nervous system. Studies indicate that elevated levels of oxidative markers and pro-inflammatory cytokines are commonly observed in individuals with schizophrenia, pointing to a potential pathophysiological link. The dysregulation of redox homeostasis may exacerbate neuroinflammatory responses, contributing to neuronal damage and the subsequent manifestation of psychiatric symptoms. Furthermore, genetic and environmental factors may …
• Macroporous hydroxyapatite-based bone scaffolds loaded with CAPE derivatives: a strategy to reduce oxidative stress and biofilm formation. [AUT. KORESP.] PAULINA KAZIMIERCZAK, [AUT.] MARWA BALAHA, KRZYSZTOF PALKA, JOANNA WESSELY-SZPONDER, MICHAŁ WÓJCIK, VIVIANA DI GIACOMO, BARBARA DE FILIPPIS, AGATA PRZEKORA. Materials [online] 2025 vol. 18 nr 22 [art. nr] 5074, s. 1-17, bibliogr. poz. 45, [przeglądany 13 listopada 2024]. Dostępny w: https://www.mdpi.com/1996-1944/18/22/5074. DOI: 10.3390/ma18225074
  Caffeic acid phenethyl ester (CAPE), a polyphenol from propolis, is well recognized for its anti-inflammatory, antioxidant, antimicrobial, and osteogenic properties. This study aimed to develop macroporous bone scaffolds composed of a chitosan/agarose matrix reinforced with nanohydroxyapatite and enriched with stable CAPE derivatives to enhance their biomedical potential for applications in bone tissue engineering and regenerative medicine. A comprehensive evaluation of microstructural and biological properties of the produced scaffolds was conducted. The fabricated scaffolds exhibited high porosity (49–60%) with interconnected pores and compressive strength (1.2–1.8 MPa), closely resembling cancellous bone and indicating suitability for bone regeneration. They were biocompatible, promoted osteoblast adhesion, proliferation, and differentiation, and supported apatite deposition on their surfaces, demonstrating strong bioactivity and potential for implant osseointegration. Importantly, the scaffolds did not trigger excessive production of reactive oxygen …
• The role of toll-like receptors and viral infections in the pathogenesis and progression of pulmonary arterial hypertension - a narrative review. [AUT.] AGNIESZKA STYCZEŃ, MARTYNA KRYSA, [AUT. KORESP.] PAULINA MERTOWSKA, [AUT.] EWELINA GRYWALSKA, TOMASZ URBANOWICZ, MACIEJ KRASIŃSKI, MALWINA GROBELNA, WERONIKA TOPYŁA-PUTOWSKA, MANSUR RAHNAMA-HEZAVAH, MICHAŁ TOMASZEWSKI. Int. J. Mol. Sci. [online] 2025 vol. 26 nr 22 [art. nr] 11143, s. 1-38, bibliogr. poz. 294, [przeglądany 19 listopada 2025]. Dostępny w: https://www.mdpi.com/1422-0067/26/22/11143. DOI: 10.3390/ijms262211143
  Aberrant activation of innate immunity promotes the development of pulmonary arterial hypertension (PAH); however, the role of pattern recognition by Toll-like receptors (TLRs) within the pulmonary vasculature remains unclear. To consolidate knowledge (as of June 2025) about TLRs and their interactions with viruses in PAH and to identify therapeutic implications. A narrative review of experimental and clinical studies investigating ten TLRs in the context of the pulmonary vascular microenvironment and viral infections. Activation of TLR1/2, TLR4, TLR5/6, TLR7/8, and TLR9 converges on the MyD88–NF-κB/IL-6 axis, thereby enhancing endothelial-mesenchymal transition, smooth muscle proliferation, oxidative stress, thrombosis, and maladaptive inflammation, ultimately increasing pulmonary vascular resistance. Conversely, TLR3, through TRIF–IFN-I, preserves endothelial integrity and inhibits vascular remodeling; its downregulation correlates with PAH severity, and poly (I:C) restitution has been shown to improve hemodynamics …
• Personalized medicine in pulmonary arterial hypertension: utilizing artificial intelligence for death prevention. [AUT.] ŁUKASZ LEDZIŃSKI, [AUT. KORESP.] GRZEGORZ GRZEŚK, [AUT.] MICHAŁ ZIOŁKOWSKI, MARCIN WALIGÓRA, MARCIN KURZYNA, TATIANA MULAREK-KUBZDELA, ANNA SMUKOWSKA-GORYNIA, ILONA SKOCZYLAS, ŁUKASZ CHRZANOWSKI, PIOTR BŁASZCZAK, MIŁOSZ JAGUSZEWSKI, BEATA KUŚMIERCZYK-DROSZCZ, KATARZYNA PTASZYŃSKA, KATARZYNA MIZIA-STEC, EWA MALINOWSKA, MAŁGORZATA PEREGUD-POGORZELSKA, EWA LEWICKA, MICHAŁ TOMASZEWSKI, WOJCIECH JACHEĆ, MICHAŁ FLORCZYK, EWA MROCZEK, ZBIGNIEW GĄSIOR, AGNIESZKA PAWLAK, KATARZYNA BETKIER-LIPIŃSKA, PIOTR PRUSZCZYK, OLGA DZIKOWSKA-DIDUCH, KATARZYNA WIDEJKO, JUDYTA WINOWSKA-JÓZWA, GRZEGORZ KOPEĆ. J. Clin. Med. [online] 2025 vol. 14 nr 23 [art. nr] 8325, s. 1-15, bibliogr. poz. 37, [przeglądany 3 grudnia 2025]. Dostępny w: https://www.mdpi.com/2077-0383/14/23/8325. DOI: 10.3390/jcm14238325
  Background/Objectives: Pulmonary arterial hypertension (PAH) is a complex cardiovascular disease with a high burden of morbidity and mortality. Although several risk prediction models have been proposed, the exact significance of distinct clinical parameters in predicting survival in PAH remains unclear. It is important to emphasize that this study does not aim to validate or contradict existing clinical risk assessment calculators provided by the ESC or other scientific societies. Instead, the goal of this research is to identify and rank clinical parameters according to their importance in predicting mortality in PAH patients using machine learning techniques. Methods: Using the Database of Pulmonary Hypertension in the Polish population (BNP-PL) registry, 1755 adult patients with PAH were selected. Feature engineering was conducted using domain knowledge, guided by European Society of Cardiology (ESC) recommendations. …