1Wyszukiwanie od początku wyrazu: Wyraz preane znajdzie "preanestetyczny", ale anestetyczny nie znajdzie tego słowa (wyszukiwanie patrzy tylko na początek wyrazów)
-Wykluczanie słów (znak minus): Poprzedzenie wyrazu znakiem - znajdzie wszystkie tytuły NIE zawierające danego słowa, np. -onkologia znajdzie prace bez słowa "onkologia"
"Wyszukiwanie całych fraz (cudzysłów): Cudzysłów powoduje szukanie całych ciągów znaków w tej samej kolejności. Np. "Uniwersytet Medyczny" wyszuka tylko prace z dokładnie tą nazwą, podczas gdy wpisanie bez cudzysłowu może znaleźć "Medyczny Uniwersytet"
↕Nawigacja klawiaturą: Użyj / aby otworzyć wyszukiwanie, strzałek ↑↓ do nawigacji po wynikach, ENTER aby przejść do wybranej pozycji, lub ESC aby zamknąć okno
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Biblioteka informuje, że dla artykułów z lat 2024-2025 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2025
Biblioteka informuje, że dla artykułów z lat 2023-2024 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2024
Biblioteka informuje, że dla artykułów z lat 2022-2023 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2023
The growing popularity of Internet trends promoting poisonous mushrooms as ‘natural therapies’ poses a risk for public health. Amanita phalloides is a highly hepatotoxic species that can cause acute liver failure, while neurological complications are rare. The case is reported of a 57-year-old woman with depression, admitted after a generalized tonic-clonic seizure. She had ingested dried Amanita phalloides for three weeks, and the day before admission an additional powdered dose, which caused diarrhea, loss of consciousness, and convulsions. Believing in the therapeutic effect, she had also placed mushroom fragments in the umbilical region. Laboratory tests showed elevated creatine kinase and mildly increased aminotransferases; EEG revealed temporo-parieto-occipital abnormalities. Supportive treatment led to clinical improvement. The case highlights the risks of Internet-based pseudotherapies, and the importance of thorough history-taking. KEYWORDS:Amanita phalloides; Amanita …
ABSTRACTBackgroundTriggering receptor expressed on myeloid cells 2 (TREM2) is a microglia surface receptor that aids in tissue repair and debris clearance. The soluble form, sTREM2, found in both blood and cerebrospinal fluid, is considered a biomarker for microglial activation. Based on the central role of microglia in MS pathogenesis, we aimed to investigate whether serum sTREM2 levels could predict disability progression in patients with primary progressive MS.MethodsSerum levels of sTREM2 were measured at baseline using a single‐molecule array assay in a multicenter cohort of 137 primary progressive multiple sclerosis (PPMS) patients. Univariable and multivariable linear models evaluated the association between sTREM2 levels and EDSS change at 2 years, 6 years, and last follow‐up.ResultsWhile …
Abstract A hybrid method combining biomimetic liquid chromatography with immobilized artificial membrane (IAM) and quantitative structure–activity relationships (QSARs) was used to derive helpful models for predicting selected properties related to distribution (binding to human serum albumin (log Pw/HSA)) and absorption (skin permeation (log Kw/sp), plant cuticle permeation (log Pw/pc), and human intestinal permeability (Caco-2)), and therefore influencing the effectiveness or unwanted effects of 199 synthetic compounds that are regarded as potential drugs or plant protection products. The molecules under investigation—derivatives of 5H-6,7-dihydroimidazo [2,1-c][1,2,4]triazole, 7,8-dihydroimidazo[2,1-c][1,2,4]triazin-4(6H)-one, 2,6,7,8-tetrahydroimidazo[2,1-c][1,2,4]triazine-3,4-dione, 1H-1,2,4-triazole, carbamic and phenoxyacetic acid—differ in their properties but all meet the requirements for xenobiotics to be considered as medicinal products. Reliable high-concept models were developed, indicating lipophilicity, molecular size, electronic properties, and the number of rotatable bonds as descriptors that determine the biological properties …
Keywords venous thromboembolism, injury, Doppler ultrasound, intramuscular vein thrombosis Abstract Introduction: Venous thromboembolism is a common clinical problem. Its diagnosis in patients who have sustained trauma can be difficult due to nonspecific symptoms and the lack of characteristic findings on imaging studies. Thrombosis of the intramuscular veins of the lower leg is an uncommon manifestation of thrombotic disease, and due to its location and difficult diagnosis, it remains an underestimated and overlooked cause of painful lower limb edema. Case description: A 36-year-old man who suffered a knee injury while skiing presented with persistent swelling of the knee and shin lasting three weeks. Magnetic resonance imaging and ultrasound examination revealed no significant pathology, intra-articular damage, cartilaginous structures. An initial assessment of the venous system revealed no significant changes in the popliteal …
The study evaluated whether a single oral administration of lectin extracted from common beans (Phaseolus vulgaris) at 12 weeks of age influences intestinal morphology and bone structure in roosters and capons. A total of 320 male birds were allocated to four experimental groups based on hormonal status and lectin treatment. Birds in the lectin-supplemented groups received a single gastric dose of lectin at 100 mg/kg body weight. Growth performance, carcass traits, intestinal histomorphometry, and tibial geometry and mechanical properties were assessed at 24 weeks of age. Lectin administration induced significant changes in jejunal morphology, with the most pronounced effects observed in capons. These effects were less pronounced in hormonally intact roosters. The effects on bone were limited and included slight differences in marrow cavity dimensions, without improvements in mineralization or …
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