1Wyszukiwanie od początku wyrazu: Wyraz preane znajdzie "preanestetyczny", ale anestetyczny nie znajdzie tego słowa (wyszukiwanie patrzy tylko na początek wyrazów)
-Wykluczanie słów (znak minus): Poprzedzenie wyrazu znakiem - znajdzie wszystkie tytuły NIE zawierające danego słowa, np. -onkologia znajdzie prace bez słowa "onkologia"
"Wyszukiwanie całych fraz (cudzysłów): Cudzysłów powoduje szukanie całych ciągów znaków w tej samej kolejności. Np. "Uniwersytet Medyczny" wyszuka tylko prace z dokładnie tą nazwą, podczas gdy wpisanie bez cudzysłowu może znaleźć "Medyczny Uniwersytet"
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Biblioteka informuje, że dla artykułów z lat 2024-2025 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2025
Biblioteka informuje, że dla artykułów z lat 2023-2024 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2024
Biblioteka informuje, że dla artykułów z lat 2022-2023 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2023
Abstract The development of new methods enhancing the growth and yield of cereals is still needed in crop production due to their great importance in human diet and as livestock fodder. In our study, new fertilizer-biostimulators with micro- and macroelements and extract containing lipochitooligosaccharides (LCOs) produced by Rhizobium leguminosarum bv. trifolii were used for stimulation of growth of barley and triticale in greenhouse conditions. The preparations were applied at the tillering and shooting stages, whereas plant traits were studied at flowering and at full maturity. The best results were recorded after the joint treatment of the plants with LCOs and mineral fertilization. The application of such a mixture significantly increased the length and mass of roots at flowering in both studied species. A beneficial effect of the treatment was also …
Various drug classes target B-cell maturation antigen (BCMA) including chimeric antigen receptor T-cell (CAR-T) therapies, bispecific antibodies (bsAbs), and antibody-drug conjugates (ADCs). Outcomes with CAR-T and bsAb therapies in multiple myeloma (MM) have been affected by T-cell exhaustion, and abrogated expression/mutation of the BCMA target has been observed with anti-BCMA therapies. Optimal anti-BCMA sequencing strategies are needed to improve long-term clinical outcomes. We used data from multiple clinical studies of the ADC belantamab mafodotin (as monotherapy and combination regimens) to explore its impact on BCMA levels and binding (using electrochemiluminescence methodology) and T-cell/natural killer (NK) cell fitness (including cell counts, expression of functional markers), to determine whether belantamab mafodotin could be sequenced ahead of other BCMAtargeting therapies for MM. Levels of free soluble BCMA (sBCMA), measured at the best-confirmed response …
Abstract Usnic acid (UA) is one of the most extensively studied specialized metabolites of lichens, attracting considerable interest due to its antimicrobial, anti-inflammatory, and cytotoxic properties. The efficiency of UA extraction from lichens depends on multiple interrelated biological and technological factors. This systematic review aims to synthesize and critically evaluate reported strategies for UA extraction from wild-grown lichen biomass, with particular emphasis on extraction efficiency, practicality, and application potential. This systematic literature review, based on the Scopus database was conducted by including original research articles reporting UA extraction from wild-growing lichens. The analysis covered species selection, sample pre-treatment, solvent type, and extraction methodology. A total of 117 studies were included. Due to the predominantly non-polar nature of UA, higher extraction efficiencies were generally achieved using solvents, including acetone, supercritical CO2, …
Abstract The aim of this study was to evaluate the phytochemical profile and neuroprotective potential of extracts from underground and aerial parts of two Carlina species: Carlina acaulis (CA) and Carlina vulgaris (CV). Metabolic profiling performed via UHPLC-UV-MS/MS revealed a distinct chemotaxonomic differentiation between the taxa. C. acaulis was defined as a “phenolic-acid” chemotype dominated by 5-O-caffeoylquinic acid (up to 32.11 mg/g in leaves), whereas C. vulgaris was characterized as a “flavonoid” chemotype, distinguished by a unique C-glycoside signature, including carlinoside and schaftoside. A significant aspect of scientific novelty is the first-ever identification of flavonolignans (e.g., salcolin A/B and tricin derivatives) in the roots of both species. In biological assays, the extracts demonstrated a multidirectional neuroprotective mechanism. Good antioxidant properties (DPPH, FRAP assays) were confirmed, particularly in CA leaves and …
Immunoglobulin A nephropathy (IgAN) is the most common glomerulonephritis worldwide. Xanthohumol (XN) exhibits anti-inflammatory, anti-oxidant, anti-fibrotic, anti-microbial, anti-proliferative, and immunomodulatory effects that all are associated with the IgAN pathogenesis. Our study aims to evaluate the potential impact of XN on the clinical course of IgAN refractory to conventional treatment. Included were five rigorously selected IgAN patients with poor prognosis assessed on the basis of clinical findings and renal biopsy. Patients received XN orally at a daily dose of 2 mg/kg body weight. Biochemical tests were performed the day before the start of XN administration, and then after 2, 4, 12, 24, and 52 weeks of XN administration. XN induced a decrease in daily proteinuria in all patients. Compared to baseline values, at T52 the mean reduction in proteinuria and albumin-creatinine-ratio …
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