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• Modulation of the kynurenine pathway: A new approach for treating neurodegeneration. [AUT.] JULIA K. BANASZKIEWICZ, ANNA KUKIEŁKA, ELŻBIETA KUDYK, ŁUCJA J. WALCZAK, KATARZYNA WICHA-KOMSTA, MARIOLA HERBET, IWONA PIĄTKOWSKA-CHMIEL, GRZEGORZ NOWICKI, CARMEN E. MIELNIK, [AUT. KORESP.] TOMASZ KOCKI. Life [online] 2026 vol. 16 nr 2 [art. nr] 266, s. 1-42. bibliogr. poz. 221, [przeglądany 3 lutego 2026]. Dostępny w: https://www.mdpi.com/2075-1729/16/2/266. DOI: 10.3390/life16020266
  03.02.2026 19:22 • 2026
• Plasma HMGB1 as a potential biomarker reflecting the clinical outcome in chronic heart failure patients. [AUT. KORESP.] MARCIN MAZUREK, [AUT.] ANETA SKWAREK-DZIEKANOWSKA, GRZEGORZ SOBIESZEK, TERESA MAŁECKA-MASSALSKA, TOMASZ POWRÓZEK. J. Clin. Med. [online] 2026 vol. 15 nr 3 [art. nr] 1159, s. 1-18, bibliogr. poz. 34, [przeglądany 2 lutego 2026]. Dostępny w: https://www.mdpi.com/2077-0383/15/3/1159. DOI: 10.3390/jcm15031159
  03.02.2026 19:10 • 2026
• Volumetric differences in the brain in children with hypoxic-ischemic encephalopathy after therapeutic hypothermia: a review of MRI findings. [AUT. KORESP.] BARTŁOMIEJ SYZDOŁ, [AUT.] KAMILA ĆWIK, MAGDALENA WOŹNIAK. Pol. J. Radiol. [online] 2026 vol. 91 nr 1 s. e37-e44, bibliogr. poz. 44, [przeglądany 2 lutego 2026]. Dostępny w: https://www.polradiol.com/Volumetric-differences-in-the-brain-in-children-with-hypoxic-ischemic-encephalopathy,211222,0,2.html. DOI: 10.5114/pjr/211222
  03.02.2026 17:17 • 2026
• Experimental models and translational strategies in neuroprotective drug development with emphasis on Alzheimer’s disease. [AUT.] PRZEMYSŁAW NIZIŃSKI, KAROLINA SZALAST, ANNA MAKUCH-KOCKA, KINGA PARUCH-NOSEK, MAGDALENA CIECHANOWSKA, [AUT. KORESP.] TOMASZ PLECH. Molecules [online] 2026 vol. 31 nr 2 [art. nr] 320, s. 1-44, bibliogr. poz. 359, [przeglądany 3 lutego 2026]. Dostępny w: https://www.mdpi.com/1420-3049/31/2/320. DOI: 10.3390/molecules31020320
  03.02.2026 14:50 • 2026
• Bispecific T-cell engagers, cell therapies, and other non-checkpoint immunotherapies for metastatic uveal melanoma: a narrative review. [AUT.] JAKUB KLEINROK, WERONIKA PAJĄK, JOANNA PEC, KAMIL RUSZTYN, [AUT. KORESP.] JOANNA DOLAR-SZCZASNY, [AUT.] ALICJA FORMA, GRZEGORZ TERESIŃSKI, [AUT. KORESP.] JACEK BAJ. J. Clin. Med. [online] 2026 vol. 15 nr 2 [art. nr] 641, s. 1-31, bibliogr. poz. 53, [przeglądany 14 stycznia 2026]. Dostępny w: https://www.mdpi.com/2077-0383/15/2/641. DOI: 10.3390/jcm15020641
  03.02.2026 14:09 • 2026
• Ocena stężenia amin katecholowych oraz ekspresji mikroRNA-29b u pacjentów przewlekle hemodializowanych. [AUT.] MARCIN DZIEDZIC, EWELINA ORŁOWSKA-DZIEDZIC, TOMASZ POWRÓZEK, MAGDALENA HAŁABIŚ-KALINOWSKA, KINGA GAWEŁ, ANNA BEDNAREK-SKUBLEWSKA, TERESA MAŁECKA-MASSALSKA, JANUSZ SOLSKI. Diag. Lab. 2017 vol. 53 suppl. 1 s. 54, XIX Zjazd Naukowy Polskiego Towarzystwa Diagnostyki Laboratoryjnej. Kraków, 3-6 września 2017 r. Streszcz.
  03.02.2026 13:59 • 2017
• MIR-138-5P as a predictive factor of severe oral mucositis in patients with head and neck cancer undergoing intensity - modulated radiation therapy. [AUT.] R[ADOSŁAW] MLAK, I[WONA] HOMA-MLAK, T[OMASZ] POWRÓZEK, M[ARCIN] MAZUREK, A. BRZOZOWSKA, T[ERESA] MAŁECKA-MASSALSKA. J. Physiol. Pharmacol. 2021 vol. 72 suppl. 1 s. 114, 28th Congress of the Polish Physiological Society. Gdańsk, September 15-17, 2021 [online]. Abstr. [przeglądany 12 października 2021]. Dostępny w: https://ptf.gumed.edu.pl/registration-abstracts/.
  03.02.2026 13:56 • 2021
• MIR 511-5P expression as a predictor of nutritional status disorders in patients treated with intensity-modulated radiation theraphy due to head neck cancer. [AUT.] M[ARCIN] MAZUREK, R[ADOSŁAW] MLAK, I[WONA] HOMA-MLAK, T[OMASZ] POWRÓZEK, A. BRZOZOWSKA, T[ERESA] MAŁECKA-MASSALSKA. J. Physiol. Pharmacol. 2021 vol. 72 suppl. 1 s. 176, 28th Congress of the Polish Physiological Society. Gdańsk, September 15-17, 2021 [online]. Abstr. [przeglądany 12 października 2021]. Dostępny w: https://ptf.gumed.edu.pl/registration-abstracts/.
  03.02.2026 13:56 • 2021
• Association between depression and unfavorable nutritional, cardiac and laboratory outcomes in patients with chronic heart failure. [AUT.] G[RZEGORZ] OPIELAK, T[OMASZ] POWRÓZEK, A. SKWAREK-DZIEKANOWSKA, G. SOBIESZEK, T[ERESA] MAŁECKA-MASSALSKA. J. Physiol. Pharmacol. 2021 vol. 72 suppl. 1 s. 86, 28th Congress of the Polish Physiological Society. Gdańsk, September 15-17, 2021 [online]. Abstr. [przeglądany 14 października 2021]. Dostępny w: https://ptf.gumed.edu.pl/registration-abstracts/.
  03.02.2026 13:56 • 2021
• Single nucleotide polymorphism of the promoter of TNFRSF1A gene (-610T G, RS4149570) as a useful predictor of malnutrition in patients treated with intensity-modulated radiation therapy due to head and neck cancer. [AUT.] I[WONA] HOMA-MLAK, R[ADOSŁAW] MLAK, M[ARCIN] MAZUREK, A. BRZOZOWSKA, T[OMASZ] POWRÓZEK, T[ERESA] MAŁECKA-MASSALSKA. J. Physiol. Pharmacol. 2021 vol. 72 suppl. 1 s. 104, 28th Congress of the Polish Physiological Society. Gdańsk, September 15-17, 2021 [online]. Abstr. [przeglądany 12 października 2021]. Dostępny w: https://ptf.gumed.edu.pl/registration-abstracts/.
  03.02.2026 13:56 • 2021
• CircNT5E-a promising new player in glioblastoma tumorigenesis. [AUT. KORESP.] TOMASZ POWRÓZEK, [AUT.] TERESA MAŁECKA-MASSALSKA. Transl. Cancer Res. 2018 vol. 7 nr 6 s. 1341-1343, bibliogr. DOI: 10.21037/tcr.2018.10.09
  03.02.2026 13:43 • 2018
• Circular RNAs-a missing piece in pulmonary macrophage activation in silica-induced inflammation. [AUT. KORESP.] TOMASZ POWRÓZEK, [AUT.] TERESA MAŁECKA-MASSALSKA. Transl. Cancer Res. 2018 vol. 7 suppl. 5 s. S597-S599, bibliogr. DOI: 10.21037/tcr.2018.05.26
  03.02.2026 13:42 • 2018

Najnowsze rekordy ze streszczeniem

• Experimental models and translational strategies in neuroprotective drug development with emphasis on Alzheimer’s disease. [AUT.] PRZEMYSŁAW NIZIŃSKI, KAROLINA SZALAST, ANNA MAKUCH-KOCKA, KINGA PARUCH-NOSEK, MAGDALENA CIECHANOWSKA, [AUT. KORESP.] TOMASZ PLECH. Molecules [online] 2026 vol. 31 nr 2 [art. nr] 320, s. 1-44, bibliogr. poz. 359, [przeglądany 3 lutego 2026]. Dostępny w: https://www.mdpi.com/1420-3049/31/2/320. DOI: 10.3390/molecules31020320
  Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are becoming more prevalent and still lack effective disease-modifying therapies (DMTs). However, translational efficiency remains critically low. For example, a ClinicalTrials.gov analysis of AD programs (2002–2012) estimated ~99.6% attrition, while PD programs (1999–2019) achieved an overall success rate of ~14.9%. In vitro platforms are assessed, ranging from immortalized neuronal lines and primary cultures to human-induced pluripotent stem cell (iPSC)-derived neurons/glia, neuron–glia co-cultures (including neuroinflammation paradigms), 3D spheroids, organoids, and blood–brain barrier (BBB)-on-chip systems. Complementary in vivo toxin, pharmacological, and genetic models are discussed for systems-level validation and central nervous system (CNS) exposure realism. The therapeutic synthesis focuses on AD, covering symptomatic drugs, anti-amyloid immunotherapies, tau-directed approaches, and repurposed drug classes that target …
• Serum 25-hydroxyvitamin D levels in breast cancer patients: a cross-sectional analysis by molecular tumor subtypes. [AUT.] DOROTA WEBER, ANDRZEJ STANISŁAWEK, ANNA IRZMAŃSKA-HUDZIAK, TERESA KULIK, [AUT. KORESP.] ANNA B. PACIAN, [AUT.] MONIKA BARYŁA-MATEJCZUK, MARTA ŁUCZYK, ROBERT ŁUCZYK. J. Clin. Med. [online] 2026 vol. 15 nr 2 [art. nr] 833, s. 1-16, bibliogr. poz. 30, [przeglądany 21 stycznia 2026]. Dostępny w: https://www.mdpi.com/2077-0383/15/2/833. DOI: 10.3390/jcm15020833
  Background: Vitamin D deficiency has been implicated in breast cancer pathogenesis and prognosis. However, the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and molecular breast cancer subtypes remains incompletely understood. Methods: This cross-sectional study included 168 women (89 breast cancer patients, 79 healthy controls) from Poland. Serum 25(OH)D was measured by electrochemiluminescence immunoassay. Blood samples were collected year-round, with 54% obtained during winter/spring months (October–March). Molecular subtypes (luminal A, luminal B, HER2-enriched, triple-negative) were classified by immunohistochemistry. Results: Mean 25(OH)D was 30 ± 13 ng/mL, with 55% showing insufficiency (<30 ng/mL). No significant differences were observed between patients and controls (p = 0.93). A borderline non-significant trend was observed across molecular subtypes (p = 0.055). HER2-enriched tumors showed descriptively higher concentrations (37.6 ng/mL, 95% CI: 29.5–45.8) compared to luminal A …
• Global consensus for the screening, diagnosis, staging, treatment, and surveillance of ovarian cancer in areas of significant resource limitations: report from the International Gynecological Cancer Society consensus meeting. [AUT.] FERNANDO MALUF, [AUT. KORESP.] HENRIQUE A. HELBER, [AUT.] FRANCINNE TOSTES, LIGIA A. MALUF, JULIANA K. HELITO, RENATO MORETTI-MARQUES, GRAZIELA Z. DAL MOLIN, BRUNO ROBERTO B. AZEVEDO, DAVID I. ORTIZ, DAVID CANTU, AGNALDO L. SILVA FILHO, ANGELICA NOGUEIRA-RODRIGUES, REITAN RIBEIRO, GEORGIA F. CINTRA, GUSTAVO GUITMANN, ANDREIA CRISTINA DE MELO, EDUARDO PAULINO, GLAUCO BAIOCCHI, LEANDRO RESENDE, MICHELLE S. DE ALMEIDA, DIOCESIO A. DE ANDRADE, JULIO L. DE LA VEGA, FLORENCIA NOLL, FABIO FIN, ANDRE LOPES, MIGUEL E. CORREA, JOSEPH S. NG, DANIEL SANABRIA, GABRIEL RENDON, FERNANDO HEREDIA, ANA PAULA E. LOPES, MYRIAM B. MUSSI, MARCIN BOBIŃSKI, MILAGROS P. QUINTANILLA, JIMENA MEYMAR, DAVID ATALLAH, AUDREY TSUNODA. Front. Oncol. [online] 2025 vol. 15 [art. nr] 1677427, s. 1-7, bibliogr, [przeglądany 2 lutego 2026]. Dostępny w: https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2025.1677427/full. DOI: 10.3389/fonc.2025.1677427
  IntroductionThe objective of this consensus report is to provide practical, resource-stratified recommendations for the management of ovarian cancer in countries with limited resources, where direct application of international guidelines is often difficult. To address these challenges, recommendations were developed from a panel of international experts.MethodsThe panel met in New York in September/October 2022 during the International Gynecological Cancer Society congress and was composed of specialists from countries in Africa, Asia, Eastern Europe, Latin America, and the Middle East. The panel addressed 72 questions and provided recommendations for the diagnosis, staging, treatment, and surveillance of ovarian cancer. Consensus was defined as at least 75% of the voting members selecting a particular recommendation, whereas a majority vote was considered when one option garnered between 50% and …
• N-acetyl-L-cysteine affects ototoxicity evoked by amikacin and furosemide either alone or in combination in a mouse model of hearing threshold decrease. [AUT. KORESP.] MAREK ZADROŻNIAK, [AUT.] MARCIN SZYMAŃSKI, JAROGNIEW ŁUSZCZKI. Int. J. Mol. Sci. [online] 2023 vol. 24 nr 8 [art. nr] 7596, s. 1-13, bibliogr. poz. 51, [przeglądany 28 kwietnia 2023]. Dostępny w: https://www.mdpi.com/1422-0067/24/8/7596. DOI: 10.3390/ijms24087596
  Drug-induced ototoxicity resulting from therapy with aminoglycoside antibiotics and loop diuretics is one of the main well-known causes of hearing loss in patients. Unfortunately, no specific protection and prevention from hearing loss are recommended for these patients. This study aimed at evaluating the ototoxic effects produced by mixtures of amikacin (AMI, an aminoglycoside antibiotic) and furosemide (FUR, a loop diuretic) in the mouse model as the hearing threshold decreased by 20% and 50% using auditory brainstem responses (ABRs). Ototoxicity was produced by the combinations of a constant dose of AMI (500 mg/kg; i.p.) on FUR-induced hearing threshold decreases, and a fixed dose of FUR (30 mg/kg; i.p.) on AMI-induced hearing threshold decreases, which were determined in two sets of experiments. Additionally, the effects of N-acetyl-L-cysteine (NAC; 500 mg/kg; i.p.) on …
• Manufacturing technology of banded pseudo-spiral bracelets in the light of experimental studies and computed tomography. [AUT.] ALBIN SOKÓŁ, MARCIN MACIEJEWSKI, ŁUKASZ SZCZEPAŃSKI, TYMOTEUSZ KOSIŃSKI, MICHAŁ TRACZ. Sprawozd. Archeol. 2025 vol. 77 nr 1 s. 285-303, bibliogr. poz. 43. DOI: 10.23858/sa/77.2025.1.4042
  Knowledge of manufacturing technology of items from various raw materials not only allows for a better understanding of the spheres of human culture associated with their production but also provides a basis for further conclusions on the functioning of prehistoric communities. Copper-alloy objects might be examined using a wide range of archaeometallurgical methods. In this paper, we would like to focus on the manufacturing technology of banded pseudo-spiral bracelets, using an archaeological experiment, macro- and microscopic analyses of traces on copper-alloy items and computed tomography of artefacts from the Lubnowy Wielkie hoard, dated to the Late Bronze Age, Montelius’ V period, as well as their reconstructions made during the experiment.