1Wyszukiwanie od początku wyrazu:Wyraz preane znajdzie "preanestetyczny", ale anestetyczny nie znajdzie tego słowa (wyszukiwanie patrzy tylko na początek wyrazów)
-Wykluczanie słów (znak minus):Poprzedzenie wyrazu znakiem - znajdzie wszystkie tytuły NIE zawierające danego słowa, np. -onkologia znajdzie prace bez słowa "onkologia"
"Wyszukiwanie całych fraz (cudzysłów):Cudzysłów powoduje szukanie całych ciągów znaków w tej samej kolejności. Np. "Uniwersytet Medyczny" wyszuka tylko prace z dokładnie tą nazwą, podczas gdy wpisanie bez cudzysłowu może znaleźć "Medyczny Uniwersytet"
↕Nawigacja klawiaturą:Użyj / aby otworzyć wyszukiwanie, strzałek ↑↓ do nawigacji po wynikach, ENTER aby przejść do wybranej pozycji, lub ESC aby zamknąć okno
Porady BPP:Ładowanie porad...
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Biblioteka informuje, że dla artykułów z lat 2024-2025 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2025
Biblioteka informuje, że dla artykułów z lat 2023-2024 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2024
Biblioteka informuje, że dla artykułów z lat 2022-2023 uaktualniono punktację Impact Factor zgodnie z wartościami podanymi w bazie Journal Citation Reports edycja 2023
Background: Litsea cubeba, also known as mountain pepper, belongs to the Lauraceae family. It has been used as a traditional herbal medicine since approximately 600 A.D., for example, in traditional Chinese medicine to treat inflammation, headaches, and intoxication. Essential oil extracted from the fresh fruits of Litsea cubeba is a clear, oily liquid with various activities, including antimicrobial, antioxidant, anticancerous, anti-inflammatory, and anti-diabetic properties. L. cubeba fruit has demonstrated cytotoxic effects on human lung, liver, and oral cancer cells. It is also shown to inhibit tyrosinase and reduce melanin production in epidermal cells, leading to decreased discoloration and skin aging. Aim: The objective of this study is to provide a comprehensive report regarding the chemical composition and safety profiles, as well as the antioxidant and anti-tyrosinase activities, of Litsea cubeba …
Background/Objectives: Hemodialysis (HD) is the commonest life sustaining form of kidney replacement therapy in the world; however, this method of treatment have many adverse effects, and even a single HD session affects many organs, including the eyes. The aim of this study was to assess the effect of a single HD session on the ophthalmologic findings in patients with End-stage Renal Disease (ESRD). The second aim of the study was to examine the correlation of these changes with each other and between changes in systemic stressors related to the HD session. Methods: This was a single-center cross-sectional observational study conducted on 32 patients undergoing HD. Selected parameters of the anterior and posterior segment of the eye as well as systemic parameters were assessed before and after a single HD session. …
Abstract Some species of the genus Cousinia (family Asteraceae) are traditionally used to treat various diseases, and scientific research has demonstrated that they possess interesting biological activities. This study offers the first comprehensive evaluation of the aerial parts of Cousinia iconica Hub.-Mor, incorporating phytochemical profiling, bioactivity assays, and network pharmacology. High-resolution LC–ESI-QTOF–MS analysis revealed that the plant is rich in phenolic acids, hydroxy- and methoxy-flavonoid glycosides, and lignans. The aqueous extract contained the highest levels of total phenolics (78 mg gallic acid equivalents/g) and flavonoids (15.5 mg rutin equivalents/g). It also exhibited the strongest radical scavenging, reducing power, and metal chelating activities. Biological tests showed that, while all three organic extracts had similar cytotoxic effects against the RKO colorectal cancer cell line, none demonstrated measurable antiviral activity against HHV-1 or …
Introduction: Overtraining syndrome (OTS) is a state of excess sportsmen's overload caused by too high an intensity of training. The main cause of OTS is too big a training load. Also, they are other risk factors like restrictive diets, inordinate stress, and inflated expectations of a family and a coach. Description of the state of knowledge: despite numerous hypotheses like dysregulation of hypothalamus and pituitary, inflammatory hypothesis, and glycogen hypothesis the exact cause of OTS is not fully understood. None of these hypotheses explains completely all of the symptoms. In diagnosis, several laboratory tests are required to exclude other diseases. After it, because of possible systemic character diagnostic process of OTS is still problematic. One of the diagnostic methods relies on the measurement of hormone levels. Another potential diagnostic method …
Neurodegenerative diseases (NDDs), including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), are becoming more prevalent and still lack effective disease-modifying therapies (DMTs). However, translational efficiency remains critically low. For example, a ClinicalTrials.gov analysis of AD programs (2002–2012) estimated ~99.6% attrition, while PD programs (1999–2019) achieved an overall success rate of ~14.9%. In vitro platforms are assessed, ranging from immortalized neuronal lines and primary cultures to human-induced pluripotent stem cell (iPSC)-derived neurons/glia, neuron–glia co-cultures (including neuroinflammation paradigms), 3D spheroids, organoids, and blood–brain barrier (BBB)-on-chip systems. Complementary in vivo toxin, pharmacological, and genetic models are discussed for systems-level validation and central nervous system (CNS) exposure realism. The therapeutic synthesis focuses on AD, covering symptomatic drugs, anti-amyloid immunotherapies, tau-directed approaches, and repurposed drug classes that target …
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