Cryoapplication, a rarely used dental technique, freezes lesional tissues to disrupt them at the cellular level. The technique iss minimally invasive and suitable for specific mucosal lesions, offering a conservative option for oral pre-cancers. Studies show that cryotherapy is promising for managing pre-cancerous lesions with few complications. Cryogun and cottonswab cryotherapy effectively regress oral leukoplakia lesions. Cryotherapy advantages include bloodless application and less scarring potential, making it suitable for mucosal alterations. More research is needed to define indications, optimize use in oral pre-cancers, and address limitations to enhance outcomes compared to alternatives. This paper presents a case of treating white rough lesions on a 59-year-old female’s oral mucosa using cryoapplication and laser, and reviews their efficacy in managing oral leukoplakia and pre-cancerous conditions.