This article reviews the available research results of selected species of the genus Silphium L. (Asteraceae) as alternative plants for crops and industry. Silphium species have valuable qualities across a wide range of uses, which is very important in considering plant resources as a green alternative to a sustainable future. Species of the genus Silphium are tall perennials found in fields, prairies, open forests, and groves in the central and eastern parts of the United States and Canada. Various tribes of Native North American used Silphium for medicinal purposes. The cup plant Silphium perfoliatum L. is the most popular species of the genus Silphium due to its attractive ornamental, honey–giving, healing, and forage qualities. As the literature review shows, species of the genus Silphium are characterized by a high production potential in terms of yields and contain significant amounts of nutrients, i.e., carbohydrates, proteins, and L-ascorbic acid, as well as minerals and biologically active substances, e.g., terpenoids and essential oils, flavonoids, phenolic acids, and oleanosides. In addition, the research confirmed the possibility of using Silphium for fodder, as honeybee forage, phytoremediation plants, for reclamation of degraded land, as plants for energy purposes (biomass, biogas), and as plants that provide components with antimicrobial activity. This review largely takes into account many years of research experience conducted in Poland. Keywords: Silphium L.; sustainable development; alternative plants; plants with multidirectional utility potential