Introduction: Infective endocarditis (IE) is an infection of the endocardium, which most commonly involves the mitral and aortic valve. The estimated incidence of IE in patients with heart defects is 1–2%. One of the predisposing factor is mitral valve leaflet prolapse accompanied by incompetence. The diagnosis of IE can prove difficult due to the possible occurrence of symptoms from multiple organs. A multidisciplinary approach, and taking into consideration possible numerous complications is essential during diagnostic procedures. The clinical picture of IE includes embolic complications. The presented study describes the case of a 58-year-old male patient with a mitral defect diagnosed due to multi-cause anaemia, which delayed the diagnosis of IE. Besides anaemia, the clinical picture was dominated by numerous embolic brain lesions, being complications of IE, which caused disorientation and confusion.