Introduction: The article aims to presenting the factors that affect decision-making about vaccination against human influenza among a group of patients with cardiovascular diseases. An additional aim is to determined whether there are differences between the groups of patients involving medical and socio-organizational factors. Material and methods: Pilot studies were carried out in a Cardiology Clinic in a non-public healthcare institution in Białystok, northeast Poland, in 2018. The research tool was an independently designed 8-question questionnaire. A comparison was made between the groups distinguished during the study: patients revaccinated regularly, not vaccinated at all, and those who were vaccinated once, but refused to continue. Results: The questionnaire was answered by 71 respondents. The major medical conditions the patients included: “recurrent viral infections” (73.2%), “all influenza symptoms intensified” (64.8%), and “the number of cases per year” (81.7%). Among the social factors, the following were the most significant: “media information” (69%), “vaccination among friends and family” (69%), “information received from a doctor” (64%), as well as “knowledge about influenza” (74%). Conclusions: The groups of respondents varied significantly in their chosen decision-making factors. The regularly revaccinated pointed out a bigger significance and quantity of factors motivating for vaccination, compared to other patients. The respondents who have never been vaccinated gave a higher rank to the reasons for not doing so, compared to patients who refused to revaccinate.