Introduction: Bisphosphonate-related osteonecrosis of the jaws is an increasingly common side-effect of bisphosphonate treatment of malignant cancer of the osseous tissue. Necrotic foci of the bone with secondary inflammation are typical of the condition. The treatment is symptomatic and depends on the severity of the disease. The case is presented of BRONJ in a 66-year-old, occupationally-active female patient who had undergone implant-prosthetic treatment, and whose quality of life deteriorated significantly due to the symptoms of the disease. Bisphosphonate-related osteonecrosis of the jaw is treated conservatively at the initial stages of the disease, and surgical treatment should be avoided. Thorough oral hygiene and irrigations with chlorhexidine solution, supported by guided antibiotic therapy, are recommended. In severe cases, surgical sequestrotomy of the inflammatory foci, aimed at inhibiting or decelerating the course of the disease, is necessary.