Aleutian mink disease virus (AMDV) poses a serious threat to the fur industry worldwide, and the lack of effective treatments or vaccines makes it difficult to combat the disease. There are highly virulent strains of AMDV that cause severe symptoms, but by selecting animals with low titres of anti-AMDV antibodies, it is possible to obtain mink with increased resistance to AMDV. Immunomodulation research offers a promising prospect in combating AMDV. The literature review covered the potential use of immunomodulators, including nanoparticles and macromolecules, which can positively influence the immune response. Previous attempts to treat AMDV have not been satisfactory, nor have attempts to develop a fully effective vaccine. The use of new technologies based on cell engineering and nanotechnologies in the prevention and treatment of diseases has become a fact. Keywords: Aleutian mink disease virus; immunomodulation; immunostimulants