In coronavirus disease 2019 (COVID-19), among many protocols, lopinavir and ritonavir in individual or combined forms with other drugs have been used, causing an increase in the concentration of antiviral drugs in the wastewater and hospital effluents. In conventional wastewater treatment plants, the removal efficiency of various antiviral drugs is estimated to be low (<20 %). (allivibrio (danio (in (photolysis (pnec) a additional affect affecting allivibrio and antiviral any aquatic are as attempt bacteria be before behavior behavior, being can cause chronic concentration contact containing contrast, current danio drugs edema effect.< effectively environment, even explore fischeri fischeri). fischeri. for from hence, high if impacts in including indicates inflammation, intermediates its light. limits, lopinavir marine may minimize monitored must need ng∙l−1) no-effect obtained of on organisms. oxidative oxygen-depleted p parameters pericardial photo-induced photocatalysis) physicochemical predicted presence priority problems processes reduce removed requirements rerio rerio) rerio, result reveal ritonavir ritonavir-containing samples samples. severe shortening shows significantly. standard stress. study, survival tail, that the their therefore, this thoroughly to toxic toxicity traces treated treatment two under values wastewater water we with within zebrafish>