Cyber–physical systems (CPS) in healthcare represent a deep integration of computational intelligence, physical medical devices, and human-centric data, enabling continuous, adaptive, and personalized care. These systems combine real-time measurements, artificial intelligence (AI)-based analytics, and networked medical devices to monitor, predict, and optimize patient health outcomes. A key development in the field of CPS is the emergence of patient digital twins (DTs), virtual models of individual patients that simulate biological, behavioral, and social parameters. Using AI, DTs analyze complex medical and social data (genetics, lifestyle, environment, etc.) to support precise diagnosis and treatment planning. The implications of the bibliometric findings suggest that the field emerges from the conceptual phase, justifying the article’s emphasis on both the proposed architectures and their clinical validation. However, most research was conducted in computer science, engineering, and mathematics, rather than medicine and healthcare, suggesting an early stage of technological maturity. Leading countries were India, the United States, and China, but these countries did not have a high number of publications, nor did they record leading researchers or affiliations, suggesting significant research fragmentation. The most frequently observed Sustainable Development Goals indicate an industrial context. Reflecting insights from medical and social research, AI-based DT systems provide a holistic view of the patient, taking into account not only physiological states but also psychological and social well-being. These systems promote personalized therapy by dynamically adapting treatment based on real-time feedback from wearable sensors and electronic medical records. More broadly, CPS and DT systems increase healthcare system efficiency by reducing hospitalizations and supporting remote preventive care. Their implementation poses significant ethical and privacy challenges, particularly regarding data ownership, algorithm transparency, and patient autonomy. Keywords: healthcare; digital twin; cyber–physical system; artificial intelligence; machine learning; eHealth; user eXperience